Drug interactions
Danazol + Ulipristal
Severity: Moderate
Danazol and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor that may increase ulipristal concentrations. The clinical consequence is uncertain but could include more adverse effects. The ulipristal label advises caution with CYP3A4 inhibitors.
What this interaction means in plain words
Danazol and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4, reducing ulipristal clearance.
What to do
Counsel on possible increased adverse effects or consider an alternative emergency contraceptive. Danazol itself is not an effective contraceptive, so ensure reliable contraception.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Danazol and Ulipristal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Frequently asked questions
Can I take Danazol with Ulipristal?
MediHelp rates the interaction as moderate. Danazol and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor that may increase ulipristal concentrations. The clinical consequence is uncertain but could include more adverse effects. The ulipristal label advises caution with CYP3A4 inhibitors.
How serious is the interaction between Danazol and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on possible increased adverse effects or consider an alternative emergency contraceptive. Danazol itself is not an effective contraceptive, so ensure reliable contraception.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
