Drug interactions
Danazol + Zolpidem
Severity: Minor
Danazol and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol weakly to moderately inhibits CYP3A4 and could increase zolpidem exposure, leading to stronger or longer sedation. The clinical effect is predicted rather than well documented.
What this interaction means in plain words
Danazol and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated zolpidem metabolism by danazol.
What to do
Monitor for increased sedation and consider a lower zolpidem dose if daytime drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zolpidem
Frequently asked questions
Can I take Danazol with Zolpidem?
MediHelp rates the interaction as minor. Danazol and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol weakly to moderately inhibits CYP3A4 and could increase zolpidem exposure, leading to stronger or longer sedation. The clinical effect is predicted rather than well documented.
How serious is the interaction between Danazol and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and consider a lower zolpidem dose if daytime drowsiness occurs.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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