Drug interactions
Danshen + Ketorolac
Severity: Moderate
Danshen and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danshen has antiplatelet activity and has been reported to potentiate warfarin. Combined with ketorolac, which inhibits platelet function and can injure the gastrointestinal mucosa, bleeding risk may increase.
What this interaction means in plain words
Danshen and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of platelet aggregation by danshen constituents and COX-1 inhibition by ketorolac.
What to do
Advise patients to avoid danshen while receiving ketorolac, and watch for bruising or gastrointestinal bleeding if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Danshen with Ketorolac?
MediHelp rates the interaction as moderate. Danshen and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danshen has antiplatelet activity and has been reported to potentiate warfarin. Combined with ketorolac, which inhibits platelet function and can injure the gastrointestinal mucosa, bleeding risk may increase.
How serious is the interaction between Danshen and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid danshen while receiving ketorolac, and watch for bruising or gastrointestinal bleeding if both are used.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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