Drug interactions
Darifenacin + Dihydroergotamine intranasal
Severity: Moderate
Darifenacin and Dihydroergotamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine is a CYP3A4 substrate, and raised levels can cause vasospasm and peripheral or cerebral ischemia. Darifenacin is a weak CYP3A4 inhibitor, so the increase is likely small.
What this interaction means in plain words
Darifenacin and Dihydroergotamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Darifenacin may weakly inhibit CYP3A4, slightly reducing dihydroergotamine clearance.
What to do
Counsel on early signs of ergotism such as cold, numb or painful extremities and nausea, and stop dihydroergotamine if they occur. Consider an alternative migraine therapy in patients with vascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Dihydroergotamine intranasal?
MediHelp rates the interaction as moderate. Darifenacin and Dihydroergotamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine is a CYP3A4 substrate, and raised levels can cause vasospasm and peripheral or cerebral ischemia. Darifenacin is a weak CYP3A4 inhibitor, so the increase is likely small.
How serious is the interaction between Darifenacin and Dihydroergotamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on early signs of ergotism such as cold, numb or painful extremities and nausea, and stop dihydroergotamine if they occur. Consider an alternative migraine therapy in patients with vascular disease.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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