Drug interactions
Darifenacin + Fexinidazole
Severity: Moderate
Darifenacin and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may raise darifenacin concentrations, intensifying anticholinergic effects. Fexinidazole itself prolongs QT.
What this interaction means in plain words
Darifenacin and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibition of CYP3A4 reduces darifenacin clearance.
What to do
Monitor for anticholinergic effects and limit darifenacin to 7.5 mg daily during the short fexinidazole course, or defer darifenacin if practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Fexinidazole?
MediHelp rates the interaction as moderate. Darifenacin and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and may raise darifenacin concentrations, intensifying anticholinergic effects. Fexinidazole itself prolongs QT.
How serious is the interaction between Darifenacin and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and limit darifenacin to 7.5 mg daily during the short fexinidazole course, or defer darifenacin if practical.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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