Drug interactions
Darifenacin + Glycopyrronium tosylate
Severity: Moderate
Darifenacin and Glycopyrronium tosylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are antimuscarinics, so use together can add to dry mouth, constipation, urinary retention and blurred vision. Topical glycopyrronium has limited systemic absorption, so the effect is usually modest.
What this interaction means in plain words
Darifenacin and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for systemic anticholinergic effects such as urinary retention and constipation, and reduce use of one agent if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Glycopyrronium tosylate?
MediHelp rates the interaction as moderate. Darifenacin and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are antimuscarinics, so use together can add to dry mouth, constipation, urinary retention and blurred vision. Topical glycopyrronium has limited systemic absorption, so the effect is usually modest.
How serious is the interaction between Darifenacin and Glycopyrronium tosylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic anticholinergic effects such as urinary retention and constipation, and reduce use of one agent if they occur.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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