Drug interactions
Darifenacin + Hyoscyamine spray
Severity: Moderate
Darifenacin and Hyoscyamine spray: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine given as an oral or sublingual spray is absorbed systemically and adds to darifenacin's antimuscarinic effects. This can cause dry mouth, constipation, urinary retention and confusion.
What this interaction means in plain words
Darifenacin and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic antimuscarinic effects.
What to do
Avoid duplicate antimuscarinic therapy where possible; otherwise monitor for anticholinergic toxicity and reduce dose if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Darifenacin and Hyoscyamine spray, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Hyoscyamine spray?
MediHelp rates the interaction as moderate. Darifenacin and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine given as an oral or sublingual spray is absorbed systemically and adds to darifenacin's antimuscarinic effects. This can cause dry mouth, constipation, urinary retention and confusion.
How serious is the interaction between Darifenacin and Hyoscyamine spray?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antimuscarinic therapy where possible; otherwise monitor for anticholinergic toxicity and reduce dose if it occurs.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
