Drug interactions
Darifenacin + Indinavir
Severity: Major
Darifenacin and Indinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a potent CYP3A4 inhibitor and can markedly raise darifenacin levels, causing pronounced anticholinergic effects. Darifenacin labeling advises limiting the dose with potent inhibitors.
What this interaction means in plain words
Darifenacin and Indinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Indinavir strongly inhibits CYP3A4 metabolism of darifenacin.
What to do
Avoid if possible; otherwise limit darifenacin to 7.5 mg daily and monitor for anticholinergic toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Indinavir?
MediHelp rates the interaction as major. Darifenacin and Indinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indinavir is a potent CYP3A4 inhibitor and can markedly raise darifenacin levels, causing pronounced anticholinergic effects. Darifenacin labeling advises limiting the dose with potent inhibitors.
How serious is the interaction between Darifenacin and Indinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise limit darifenacin to 7.5 mg daily and monitor for anticholinergic toxicity.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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