Drug interactions
Darifenacin + Lumefantrine
Severity: Minor
Darifenacin and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is metabolized by CYP3A4 and may be affected by CYP3A4 inhibitors, which is relevant because of its QT effect. Darifenacin is a weak inhibitor, and lumefantrine has mild inducing potential, so changes are small.
What this interaction means in plain words
Darifenacin and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Minor bidirectional CYP3A4 effects.
What to do
No routine adjustment; monitor for darifenacin efficacy and consider ECG if other QT-prolonging agents are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Darifenacin and Lumefantrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Lumefantrine?
MediHelp rates the interaction as minor. Darifenacin and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine is metabolized by CYP3A4 and may be affected by CYP3A4 inhibitors, which is relevant because of its QT effect. Darifenacin is a weak inhibitor, and lumefantrine has mild inducing potential, so changes are small.
How serious is the interaction between Darifenacin and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for darifenacin efficacy and consider ECG if other QT-prolonging agents are used.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
