Drug interactions
Darifenacin + Meclizine
Severity: Moderate
Darifenacin and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is a first-generation antihistamine with anticholinergic action, so combining it with darifenacin adds to dry mouth, constipation, blurred vision, drowsiness and urinary retention. Older patients are at greatest risk of confusion.
What this interaction means in plain words
Darifenacin and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Meclizine belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects and sedation, and use the lowest effective doses. Prefer a less anticholinergic alternative in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Meclizine
Frequently asked questions
Can I take Darifenacin with Meclizine?
MediHelp rates the interaction as moderate. Darifenacin and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is a first-generation antihistamine with anticholinergic action, so combining it with darifenacin adds to dry mouth, constipation, blurred vision, drowsiness and urinary retention. Older patients are at greatest risk of confusion.
How serious is the interaction between Darifenacin and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and sedation, and use the lowest effective doses. Prefer a less anticholinergic alternative in older patients.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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