Drug interactions
Darifenacin + Nafcillin
Severity: Moderate
Darifenacin and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin can induce CYP3A4 and may reduce darifenacin concentrations. This could reduce the efficacy of treatment for overactive bladder.
What this interaction means in plain words
Darifenacin and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by nafcillin accelerates darifenacin metabolism.
What to do
Monitor for loss of symptom control during nafcillin therapy and adjust the darifenacin dose or choose an alternative if efficacy falls. Reassess after nafcillin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Nafcillin?
MediHelp rates the interaction as moderate. Darifenacin and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin can induce CYP3A4 and may reduce darifenacin concentrations. This could reduce the efficacy of treatment for overactive bladder.
How serious is the interaction between Darifenacin and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control during nafcillin therapy and adjust the darifenacin dose or choose an alternative if efficacy falls. Reassess after nafcillin is stopped.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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