Drug interactions
Darifenacin + Propranolol
Severity: Minor
Darifenacin and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol is partly cleared by CYP2D6, so darifenacin may modestly raise its concentrations. This may lead to more bradycardia or hypotension, although propranolol has several metabolic pathways.
What this interaction means in plain words
Darifenacin and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Propranolol belongs to Cardiovascular.
Why it happens
Darifenacin inhibits CYP2D6, which contributes to propranolol metabolism.
What to do
Monitor heart rate and blood pressure after starting darifenacin. Adjust the propranolol dose if symptomatic bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Darifenacin with Propranolol?
MediHelp rates the interaction as minor. Darifenacin and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol is partly cleared by CYP2D6, so darifenacin may modestly raise its concentrations. This may lead to more bradycardia or hypotension, although propranolol has several metabolic pathways.
How serious is the interaction between Darifenacin and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting darifenacin. Adjust the propranolol dose if symptomatic bradycardia occurs.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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