Drug interactions
Darifenacin + Triazolam
Severity: Minor
Darifenacin and Triazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is a weak CYP3A4 inhibitor and may slightly raise triazolam exposure, a sensitive CYP3A4 substrate. This could add to sedation and psychomotor impairment, though the effect is expected to be small.
What this interaction means in plain words
Darifenacin and Triazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP3A4 by darifenacin reduces triazolam metabolism.
What to do
Monitor for excess sedation and consider a lower triazolam dose in frail or elderly patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Triazolam?
MediHelp rates the interaction as minor. Darifenacin and Triazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is a weak CYP3A4 inhibitor and may slightly raise triazolam exposure, a sensitive CYP3A4 substrate. This could add to sedation and psychomotor impairment, though the effect is expected to be small.
How serious is the interaction between Darifenacin and Triazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and consider a lower triazolam dose in frail or elderly patients.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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