Drug interactions
Darifenacin + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Darifenacin and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium is an inhaled antimuscarinic and may add to the anticholinergic effects of darifenacin, such as dry mouth, constipation, urinary retention and blurred vision. Systemic exposure from inhalation is low, so clinically significant effects are uncommon.
What this interaction means in plain words
Darifenacin and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for urinary retention, constipation and ocular symptoms, particularly in elderly patients or those with glaucoma or bladder outlet obstruction. Review the need for both agents if anticholinergic effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Darifenacin and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Umeclidinium is an inhaled antimuscarinic and may add to the anticholinergic effects of darifenacin, such as dry mouth, constipation, urinary retention and blurred vision. Systemic exposure from inhalation is low, so clinically significant effects are uncommon.
How serious is the interaction between Darifenacin and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and ocular symptoms, particularly in elderly patients or those with glaucoma or bladder outlet obstruction. Review the need for both agents if anticholinergic effects occur.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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