Drug interactions
Deferasirox + Diltiazem
Severity: Moderate
Deferasirox and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may reduce diltiazem concentrations, possibly weakening blood pressure or heart rate control.
What this interaction means in plain words
Deferasirox and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Diltiazem belongs to Cardiovascular.
Why it happens
Deferasirox induces CYP3A4 and may increase diltiazem metabolism.
What to do
Monitor blood pressure and heart rate and titrate diltiazem if efficacy decreases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Diltiazem?
MediHelp rates the interaction as moderate. Deferasirox and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may reduce diltiazem concentrations, possibly weakening blood pressure or heart rate control.
How serious is the interaction between Deferasirox and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate diltiazem if efficacy decreases.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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