Drug interactions
Deferasirox + Donepezil
Severity: Minor
Deferasirox and Donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox has been shown to induce CYP3A4 in some settings, which could lower donepezil concentrations. The clinical significance is uncertain and likely small.
What this interaction means in plain words
Deferasirox and Donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deferasirox belongs to Miscellaneous; Donepezil belongs to Central Nervous System.
Why it happens
Possible CYP3A4 induction by deferasirox increases donepezil clearance.
What to do
No routine adjustment is required. Monitor cognitive and behavioral response and titrate donepezil if efficacy appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Donepezil?
MediHelp rates the interaction as minor. Deferasirox and Donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferasirox has been shown to induce CYP3A4 in some settings, which could lower donepezil concentrations. The clinical significance is uncertain and likely small.
How serious is the interaction between Deferasirox and Donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Monitor cognitive and behavioral response and titrate donepezil if efficacy appears reduced.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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