Drug interactions
Deferasirox + Estrogens conjugated synthetic
Severity: Moderate
Deferasirox and Estrogens conjugated synthetic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may reduce exposure to CYP3A4-metabolized estrogens, potentially weakening symptom control or endometrial effects.
What this interaction means in plain words
Deferasirox and Estrogens conjugated synthetic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Deferasirox induces CYP3A4, increasing estrogen metabolism.
What to do
Monitor for recurrence of menopausal symptoms or breakthrough bleeding and adjust the estrogen dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Estrogens conjugated synthetic?
MediHelp rates the interaction as moderate. Deferasirox and Estrogens conjugated synthetic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may reduce exposure to CYP3A4-metabolized estrogens, potentially weakening symptom control or endometrial effects.
How serious is the interaction between Deferasirox and Estrogens conjugated synthetic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrence of menopausal symptoms or breakthrough bleeding and adjust the estrogen dose if needed.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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