Drug interactions
Deferasirox + Ethinyl estradiol-levonorgestrel
Severity: Moderate
Deferasirox and Ethinyl estradiol-levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may lower exposure to ethinyl estradiol and levonorgestrel, potentially reducing contraceptive reliability. Deferasirox labeling advises that hormonal contraceptives may be less effective.
What this interaction means in plain words
Deferasirox and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
Why it happens
Deferasirox appears to induce metabolism, possibly via UGT or CYP3A4 pathways, of the contraceptive steroids.
What to do
Advise an additional non-hormonal contraceptive method during deferasirox therapy and for a short period after stopping.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as moderate. Deferasirox and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may lower exposure to ethinyl estradiol and levonorgestrel, potentially reducing contraceptive reliability. Deferasirox labeling advises that hormonal contraceptives may be less effective.
How serious is the interaction between Deferasirox and Ethinyl estradiol-levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during deferasirox therapy and for a short period after stopping.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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