Drug interactions
Deferasirox + Ethinyl estradiol-norgestimate
Severity: Moderate
Deferasirox and Ethinyl estradiol-norgestimate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may lower exposure to ethinyl estradiol and progestins, which could reduce contraceptive efficacy. Hormone exposure is reduced but the clinical consequence is not well quantified.
What this interaction means in plain words
Deferasirox and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Ethinyl estradiol-norgestimate belongs to Endocrine.
Why it happens
Deferasirox appears to induce metabolism of ethinyl estradiol, possibly via CYP3A4 and UGT pathways.
What to do
Advise an additional non-hormonal barrier method while on deferasirox, and consider a non-hormonal contraceptive option for reliable protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as moderate. Deferasirox and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may lower exposure to ethinyl estradiol and progestins, which could reduce contraceptive efficacy. Hormone exposure is reduced but the clinical consequence is not well quantified.
How serious is the interaction between Deferasirox and Ethinyl estradiol-norgestimate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal barrier method while on deferasirox, and consider a non-hormonal contraceptive option for reliable protection.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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