Drug interactions
Deferasirox + Etoposide
Severity: Moderate
Deferasirox and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may induce CYP3A4 and lower etoposide exposure. The clinical effect is uncertain, and both drugs can cause cytopenias.
What this interaction means in plain words
Deferasirox and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Etoposide belongs to Oncology.
Why it happens
Possible weak CYP3A4 induction by deferasirox increasing etoposide metabolism.
What to do
Monitor response to etoposide and blood counts. Reassess if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporine + Etoposide Major
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Etoposide?
MediHelp rates the interaction as moderate. Deferasirox and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may induce CYP3A4 and lower etoposide exposure. The clinical effect is uncertain, and both drugs can cause cytopenias.
How serious is the interaction between Deferasirox and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to etoposide and blood counts. Reassess if efficacy appears reduced.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporine. The full list is on the Etoposide page.
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