Drug interactions
Deferasirox + Ferrous sulfate
Severity: Moderate
Deferasirox and Ferrous sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox is an iron chelator and binds iron in the gut, so oral iron supplements are poorly absorbed. The two agents have opposing therapeutic aims, and the supplement is largely wasted.
What this interaction means in plain words
Deferasirox and Ferrous sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Ferrous sulfate belongs to Miscellaneous.
Why it happens
Deferasirox chelates ferrous iron in the gastrointestinal tract, forming complexes that are not absorbed.
What to do
Avoid giving oral iron to patients taking deferasirox unless iron deficiency is clearly documented. Monitor ferritin and hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ferrous sulfate
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Ferrous sulfate?
MediHelp rates the interaction as moderate. Deferasirox and Ferrous sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox is an iron chelator and binds iron in the gut, so oral iron supplements are poorly absorbed. The two agents have opposing therapeutic aims, and the supplement is largely wasted.
How serious is the interaction between Deferasirox and Ferrous sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving oral iron to patients taking deferasirox unless iron deficiency is clearly documented. Monitor ferritin and hemoglobin.
What other medicines interact with Ferrous sulfate?
MediHelp also lists interactions of Ferrous sulfate with, for example, Ciprofloxacin, Dimercaprol, Acetohydroxamic acid. The full list is on the Ferrous sulfate page.
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