Drug interactions
Deferasirox + Fosphenytoin
Severity: Moderate
Deferasirox and Fosphenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosphenytoin is converted to phenytoin, a potent enzyme inducer that can lower deferasirox exposure and reduce iron-chelating efficacy.
What this interaction means in plain words
Deferasirox and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Fosphenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces UGT-mediated glucuronidation of deferasirox, increasing its clearance.
What to do
Avoid if possible; otherwise consider a higher deferasirox dose per labeling and monitor serum ferritin and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferasirox
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Deferasirox with Fosphenytoin?
MediHelp rates the interaction as moderate. Deferasirox and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosphenytoin is converted to phenytoin, a potent enzyme inducer that can lower deferasirox exposure and reduce iron-chelating efficacy.
How serious is the interaction between Deferasirox and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise consider a higher deferasirox dose per labeling and monitor serum ferritin and clinical response.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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