Drug interactions
Deferasirox + Heparin
Severity: Moderate
Deferasirox and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can cause gastrointestinal ulceration and hemorrhage. Concurrent heparin raises the chance that a mucosal lesion will bleed significantly.
What this interaction means in plain words
Deferasirox and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Heparin belongs to Cardiovascular.
Why it happens
Deferasirox gastrointestinal mucosal injury combined with heparin anticoagulation increases bleeding risk.
What to do
Monitor for GI bleeding and hemoglobin, and consider gastroprotection. Also check platelets since deferasirox can cause cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Heparin?
MediHelp rates the interaction as moderate. Deferasirox and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can cause gastrointestinal ulceration and hemorrhage. Concurrent heparin raises the chance that a mucosal lesion will bleed significantly.
How serious is the interaction between Deferasirox and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and hemoglobin, and consider gastroprotection. Also check platelets since deferasirox can cause cytopenias.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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