Drug interactions
Deferasirox + Hydrocortisone
Severity: Moderate
Deferasirox and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox and corticosteroids both can cause gastrointestinal ulceration and bleeding, so combined use raises this risk. The legacy CYP3A4 note is of doubtful relevance.
What this interaction means in plain words
Deferasirox and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Hydrocortisone belongs to Endocrine.
Why it happens
Additive gastrointestinal mucosal toxicity and bleeding risk.
What to do
Monitor for GI bleeding symptoms and consider a proton pump inhibitor in higher-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Hydrocortisone?
MediHelp rates the interaction as moderate. Deferasirox and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox and corticosteroids both can cause gastrointestinal ulceration and bleeding, so combined use raises this risk. The legacy CYP3A4 note is of doubtful relevance.
How serious is the interaction between Deferasirox and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding symptoms and consider a proton pump inhibitor in higher-risk patients.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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