Drug interactions
Deferasirox + Ketorolac
Severity: Major
Deferasirox and Ketorolac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause gastrointestinal ulceration and hemorrhage, and both can impair renal function. Together the risk of serious GI bleeding and kidney injury is increased.
What this interaction means in plain words
Deferasirox and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Ketorolac belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal toxicity and nephrotoxicity, with NSAID antiplatelet effect adding to bleeding risk.
What to do
Avoid the combination where possible. If unavoidable, use the shortest ketorolac course, consider gastroprotection and monitor renal function and for GI bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Ketorolac?
MediHelp rates the interaction as major. Deferasirox and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause gastrointestinal ulceration and hemorrhage, and both can impair renal function. Together the risk of serious GI bleeding and kidney injury is increased.
How serious is the interaction between Deferasirox and Ketorolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, use the shortest ketorolac course, consider gastroprotection and monitor renal function and for GI bleeding.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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