Drug interactions
Deferasirox + Meclofenamate
Severity: Major
Deferasirox and Meclofenamate: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the gastrointestinal mucosa, and deferasirox has been associated with GI ulceration and hemorrhage. Combined use raises the risk of ulcers and bleeding. NSAIDs may also add to renal toxicity from deferasirox.
What this interaction means in plain words
Deferasirox and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive gastrointestinal mucosal toxicity and antiplatelet effect of the NSAID, plus additive nephrotoxicity.
What to do
Avoid the combination where possible; if needed, consider gastroprotection and monitor for GI bleeding, hemoglobin and serum creatinine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Meclofenamate?
MediHelp rates the interaction as major. Deferasirox and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the gastrointestinal mucosa, and deferasirox has been associated with GI ulceration and hemorrhage. Combined use raises the risk of ulcers and bleeding. NSAIDs may also add to renal toxicity from deferasirox.
How serious is the interaction between Deferasirox and Meclofenamate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, consider gastroprotection and monitor for GI bleeding, hemoglobin and serum creatinine.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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