Drug interactions
Deferasirox + Olanzapine
Severity: Moderate
Deferasirox and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can inhibit CYP1A2, the main route of olanzapine metabolism, and may raise olanzapine concentrations. This could increase sedation, orthostatic hypotension and other dose-related adverse effects.
What this interaction means in plain words
Deferasirox and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Olanzapine belongs to Central Nervous System.
Why it happens
Inhibition of CYP1A2-mediated olanzapine metabolism by deferasirox.
What to do
Monitor for increased sedation, hypotension and anticholinergic effects, and consider reducing the olanzapine dose if they develop. Reassess if deferasirox is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Olanzapine?
MediHelp rates the interaction as moderate. Deferasirox and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can inhibit CYP1A2, the main route of olanzapine metabolism, and may raise olanzapine concentrations. This could increase sedation, orthostatic hypotension and other dose-related adverse effects.
How serious is the interaction between Deferasirox and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation, hypotension and anticholinergic effects, and consider reducing the olanzapine dose if they develop. Reassess if deferasirox is stopped.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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