Drug interactions
Deferasirox + Pimozide
Severity: Major
Deferasirox and Pimozide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can inhibit CYP1A2 and induce CYP3A4, both of which are involved in pimozide metabolism, so pimozide exposure may change unpredictably. Raised pimozide levels carry a risk of QT prolongation and arrhythmia.
What this interaction means in plain words
Deferasirox and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Pimozide belongs to Central Nervous System.
Why it happens
Deferasirox inhibits CYP1A2 and induces CYP3A4, altering pimozide metabolism.
What to do
Avoid the combination if possible. If used, monitor ECG and clinical response and adjust the pimozide dose cautiously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Pimozide?
MediHelp rates the interaction as major. Deferasirox and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox can inhibit CYP1A2 and induce CYP3A4, both of which are involved in pimozide metabolism, so pimozide exposure may change unpredictably. Raised pimozide levels carry a risk of QT prolongation and arrhythmia.
How serious is the interaction between Deferasirox and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor ECG and clinical response and adjust the pimozide dose cautiously.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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