Drug interactions
Deferasirox + Polysaccharide iron
Severity: Moderate
Deferasirox and Polysaccharide iron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox is an iron chelator and will bind oral iron, reducing its absorption. Iron supplementation is also generally inappropriate in patients treated for iron overload.
What this interaction means in plain words
Deferasirox and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of iron in the gut by deferasirox prevents absorption.
What to do
Avoid iron supplements in patients receiving deferasirox for iron overload unless iron deficiency is documented; if required, expect reduced benefit and monitor ferritin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Polysaccharide iron?
MediHelp rates the interaction as moderate. Deferasirox and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox is an iron chelator and will bind oral iron, reducing its absorption. Iron supplementation is also generally inappropriate in patients treated for iron overload.
How serious is the interaction between Deferasirox and Polysaccharide iron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid iron supplements in patients receiving deferasirox for iron overload unless iron deficiency is documented; if required, expect reduced benefit and monitor ferritin.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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