Drug interactions
Deferasirox + Propranolol
Severity: Moderate
Deferasirox and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox inhibits CYP1A2, which contributes to propranolol metabolism, so propranolol levels may increase. This may enhance bradycardia and hypotension.
What this interaction means in plain words
Deferasirox and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Propranolol belongs to Cardiovascular.
Why it happens
Deferasirox inhibition of CYP1A2 reduces propranolol clearance.
What to do
Monitor heart rate and blood pressure when starting or stopping deferasirox. Reduce the propranolol dose if exaggerated beta-blockade occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Propranolol?
MediHelp rates the interaction as moderate. Deferasirox and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox inhibits CYP1A2, which contributes to propranolol metabolism, so propranolol levels may increase. This may enhance bradycardia and hypotension.
How serious is the interaction between Deferasirox and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping deferasirox. Reduce the propranolol dose if exaggerated beta-blockade occurs.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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