Drug interactions
Deferasirox + Rifampin
Severity: Moderate
Deferasirox and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent inducer of UGT enzymes and lowers deferasirox exposure. This can reduce iron chelation and allow iron overload to persist.
What this interaction means in plain words
Deferasirox and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of UGT-mediated glucuronidation increases deferasirox clearance.
What to do
Avoid if possible; if needed, increase the deferasirox dose per labeling and monitor serum ferritin, adjusting when rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Rifampin?
MediHelp rates the interaction as moderate. Deferasirox and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent inducer of UGT enzymes and lowers deferasirox exposure. This can reduce iron chelation and allow iron overload to persist.
How serious is the interaction between Deferasirox and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, increase the deferasirox dose per labeling and monitor serum ferritin, adjusting when rifampin is stopped.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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