Drug interactions
Deferasirox + Sildenafil
Severity: Minor
Deferasirox and Sildenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox has variable effects on CYP enzymes and may modestly lower exposure to CYP3A4 substrates. Sildenafil effect could be reduced, but the clinical significance is uncertain.
What this interaction means in plain words
Deferasirox and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deferasirox belongs to Miscellaneous; Sildenafil belongs to Genitourinary.
Why it happens
Possible weak CYP3A4 induction by deferasirox increasing sildenafil clearance, not firmly established.
What to do
No empirical dose change is needed; monitor for reduced sildenafil efficacy and adjust if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Sildenafil?
MediHelp rates the interaction as minor. Deferasirox and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferasirox has variable effects on CYP enzymes and may modestly lower exposure to CYP3A4 substrates. Sildenafil effect could be reduced, but the clinical significance is uncertain.
How serious is the interaction between Deferasirox and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for reduced sildenafil efficacy and adjust if response is inadequate.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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