Drug interactions
Deferasirox + Tobramycin inhaled
Severity: Moderate
Deferasirox and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can cause kidney injury and also has auditory effects. Inhaled tobramycin has low systemic absorption in most patients, but can be absorbed in those with impaired renal function and adds possible nephrotoxic and ototoxic risk.
What this interaction means in plain words
Deferasirox and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity and ototoxicity from both drugs, with systemic tobramycin exposure variable after inhalation.
What to do
Monitor serum creatinine and eGFR regularly, and ask about hearing changes or tinnitus. Consider audiometry in patients with renal impairment or prolonged combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Deferasirox and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can cause kidney injury and also has auditory effects. Inhaled tobramycin has low systemic absorption in most patients, but can be absorbed in those with impaired renal function and adds possible nephrotoxic and ototoxic risk.
How serious is the interaction between Deferasirox and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR regularly, and ask about hearing changes or tinnitus. Consider audiometry in patients with renal impairment or prolonged combined use.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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