Drug interactions
Deferoxamine + Rose hips
Severity: Moderate
Deferoxamine and Rose hips: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rose hips are a rich source of vitamin C. High-dose ascorbic acid can mobilize iron and increase its availability for chelation, which has been linked to cardiac function deterioration in iron-overloaded patients treated with deferoxamine.
What this interaction means in plain words
Deferoxamine and Rose hips can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ascorbic acid increases the pool of chelatable iron and may enhance redox-active iron toxicity to the heart during deferoxamine therapy.
What to do
Avoid high-dose rose hip or vitamin C supplements in patients with cardiac involvement on deferoxamine. If vitamin C is used, give it only after the infusion is established and monitor cardiac function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferoxamine
Frequently asked questions
Can I take Deferoxamine with Rose hips?
MediHelp rates the interaction as moderate. Deferoxamine and Rose hips can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rose hips are a rich source of vitamin C. High-dose ascorbic acid can mobilize iron and increase its availability for chelation, which has been linked to cardiac function deterioration in iron-overloaded patients treated with deferoxamine.
How serious is the interaction between Deferoxamine and Rose hips?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid high-dose rose hip or vitamin C supplements in patients with cardiac involvement on deferoxamine. If vitamin C is used, give it only after the infusion is established and monitor cardiac function.
What other medicines interact with Deferoxamine?
MediHelp also lists interactions of Deferoxamine with, for example, Ascorbic acid, Betibeglogene autotemcel, Exagamglogene autotemcel. The full list is on the Deferoxamine page.
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