Drug interactions
Delavirdine + Hydrocortisone
Severity: Minor
Delavirdine and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Delavirdine is a CYP3A4 substrate, and hydrocortisone may weakly induce this enzyme. Any reduction in delavirdine concentration is likely small, though low antiretroviral levels could favour resistance.
What this interaction means in plain words
Delavirdine and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction increases delavirdine metabolism.
What to do
No routine change is needed; monitor HIV viral load as usual. Be aware that delavirdine inhibits CYP3A4 and may raise corticosteroid exposure on prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Delavirdine and Hydrocortisone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Delavirdine with Hydrocortisone?
MediHelp rates the interaction as minor. Delavirdine and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Delavirdine is a CYP3A4 substrate, and hydrocortisone may weakly induce this enzyme. Any reduction in delavirdine concentration is likely small, though low antiretroviral levels could favour resistance.
How serious is the interaction between Delavirdine and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor HIV viral load as usual. Be aware that delavirdine inhibits CYP3A4 and may raise corticosteroid exposure on prolonged use.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
