Drug interactions
Demeclocycline + Ethinyl estradiol-norgestimate
Severity: Minor
Demeclocycline and Ethinyl estradiol-norgestimate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline antibiotics were traditionally thought to reduce contraceptive efficacy by disturbing gut flora involved in estrogen recirculation. Controlled data show no consistent reduction in hormone levels and the risk of contraceptive failure appears low.
What this interaction means in plain words
Demeclocycline and Ethinyl estradiol-norgestimate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Proposed reduction of enterohepatic recirculation of estrogen through altered gut flora, which is not well supported by pharmacokinetic studies.
What to do
No routine change is needed. Counsel patients to take the contraceptive consistently and use backup contraception if vomiting or diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Frequently asked questions
Can I take Demeclocycline with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as minor. Demeclocycline and Ethinyl estradiol-norgestimate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracycline antibiotics were traditionally thought to reduce contraceptive efficacy by disturbing gut flora involved in estrogen recirculation. Controlled data show no consistent reduction in hormone levels and the risk of contraceptive failure appears low.
How serious is the interaction between Demeclocycline and Ethinyl estradiol-norgestimate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Counsel patients to take the contraceptive consistently and use backup contraception if vomiting or diarrhea occurs.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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