Drug interactions
Demeclocycline + Ferrous sulfate
Severity: Moderate
Demeclocycline and Ferrous sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron forms poorly absorbed complexes with tetracyclines, including demeclocycline, which lowers antibiotic blood levels. This can lead to treatment failure.
What this interaction means in plain words
Demeclocycline and Ferrous sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of demeclocycline by ferrous iron in the gut reduces its absorption.
What to do
Give demeclocycline at least 2 hours before or 3 hours after the iron dose. Monitor clinical response to the antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ferrous sulfate
Frequently asked questions
Can I take Demeclocycline with Ferrous sulfate?
MediHelp rates the interaction as moderate. Demeclocycline and Ferrous sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron forms poorly absorbed complexes with tetracyclines, including demeclocycline, which lowers antibiotic blood levels. This can lead to treatment failure.
How serious is the interaction between Demeclocycline and Ferrous sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give demeclocycline at least 2 hours before or 3 hours after the iron dose. Monitor clinical response to the antibiotic.
What other medicines interact with Ferrous sulfate?
MediHelp also lists interactions of Ferrous sulfate with, for example, Ciprofloxacin, Dimercaprol, Acetohydroxamic acid. The full list is on the Ferrous sulfate page.
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