Drug interactions
Demeclocycline + Methotrexate
Severity: Minor
Demeclocycline and Methotrexate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracyclines may alter methotrexate absorption and enterohepatic circulation, with isolated reports of increased methotrexate levels. Evidence for demeclocycline in particular is limited.
What this interaction means in plain words
Demeclocycline and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible changes in gut flora and enterohepatic recirculation; mechanism not firmly established.
What to do
Monitor for signs of methotrexate toxicity and check blood counts routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Demeclocycline with Methotrexate?
MediHelp rates the interaction as minor. Demeclocycline and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracyclines may alter methotrexate absorption and enterohepatic circulation, with isolated reports of increased methotrexate levels. Evidence for demeclocycline in particular is limited.
How serious is the interaction between Demeclocycline and Methotrexate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of methotrexate toxicity and check blood counts routinely.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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