Drug interactions
Dengue vaccine + Hydrocortisone
Severity: Major
Dengue vaccine and Hydrocortisone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine, and immunosuppressive corticosteroid doses may blunt the immune response and raise the risk of vaccine-related infection. Physiologic replacement doses are generally not a concern.
What this interaction means in plain words
Dengue vaccine and Hydrocortisone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Corticosteroid immunosuppression reduces the vaccine response and may permit uncontrolled replication of live attenuated virus.
What to do
Avoid live vaccination during immunosuppressive corticosteroid therapy and delay it until the steroid dose is below the immunosuppressive range per vaccine guidance. Physiologic replacement doses do not usually require deferral.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Dengue vaccine with Hydrocortisone?
MediHelp rates the interaction as major. Dengue vaccine and Hydrocortisone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine, and immunosuppressive corticosteroid doses may blunt the immune response and raise the risk of vaccine-related infection. Physiologic replacement doses are generally not a concern.
How serious is the interaction between Dengue vaccine and Hydrocortisone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccination during immunosuppressive corticosteroid therapy and delay it until the steroid dose is below the immunosuppressive range per vaccine guidance. Physiologic replacement doses do not usually require deferral.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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