Drug interactions
Dengue vaccine + Thioguanine
Severity: Major
Dengue vaccine and Thioguanine: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine. Thioguanine-related immunosuppression may reduce the vaccine response and could permit vaccine virus disease in a severely immunocompromised patient.
What this interaction means in plain words
Dengue vaccine and Thioguanine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cytotoxic antimetabolite-induced immunosuppression reduces immune response and impairs control of the live vaccine virus.
What to do
Avoid live dengue vaccine during thioguanine therapy; vaccinate only after immune recovery per the vaccine labeling and specialist advice.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Thioguanine
Frequently asked questions
Can I take Dengue vaccine with Thioguanine?
MediHelp rates the interaction as major. Dengue vaccine and Thioguanine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine. Thioguanine-related immunosuppression may reduce the vaccine response and could permit vaccine virus disease in a severely immunocompromised patient.
How serious is the interaction between Dengue vaccine and Thioguanine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live dengue vaccine during thioguanine therapy; vaccinate only after immune recovery per the vaccine labeling and specialist advice.
What other medicines interact with Thioguanine?
MediHelp also lists interactions of Thioguanine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Thioguanine page.
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