Drug interactions
Dexamethasone-tobramycin + Diltiazem
Severity: Minor
Dexamethasone-tobramycin and Diltiazem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem is a moderate CYP3A4 inhibitor and can raise dexamethasone concentrations. With systemic dexamethasone this may increase corticosteroid effects such as hyperglycemia, fluid retention and adrenal suppression.
What this interaction means in plain words
Dexamethasone-tobramycin and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Diltiazem belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated dexamethasone metabolism by diltiazem.
What to do
No routine change is needed with topical use; with prolonged systemic dexamethasone, watch for corticosteroid excess and reduce the dose if it appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Diltiazem, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Diltiazem?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diltiazem is a moderate CYP3A4 inhibitor and can raise dexamethasone concentrations. With systemic dexamethasone this may increase corticosteroid effects such as hyperglycemia, fluid retention and adrenal suppression.
How serious is the interaction between Dexamethasone-tobramycin and Diltiazem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed with topical use; with prolonged systemic dexamethasone, watch for corticosteroid excess and reduce the dose if it appears.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
