Drug interactions
Dexamethasone-tobramycin + Fenoprofen
Severity: Moderate
Dexamethasone-tobramycin and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with an NSAID such as fenoprofen increases the risk of gastric ulceration and bleeding. Risk is greater with systemic corticosteroids and prolonged use.
What this interaction means in plain words
Dexamethasone-tobramycin and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Fenoprofen belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury from NSAID prostaglandin inhibition and corticosteroid-impaired mucosal healing.
What to do
Monitor for GI symptoms and bleeding, and consider a proton pump inhibitor for higher-risk patients. Use the shortest duration of combined therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Fenoprofen?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with an NSAID such as fenoprofen increases the risk of gastric ulceration and bleeding. Risk is greater with systemic corticosteroids and prolonged use.
How serious is the interaction between Dexamethasone-tobramycin and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI symptoms and bleeding, and consider a proton pump inhibitor for higher-risk patients. Use the shortest duration of combined therapy.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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