Drug interactions
Dexamethasone-tobramycin + Glecaprevir / pibrentasvir
Severity: Moderate
Dexamethasone-tobramycin and Glecaprevir / pibrentasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic dexamethasone may induce CYP3A4 and lower glecaprevir/pibrentasvir exposure, risking reduced antiviral efficacy. The combination may also raise dexamethasone through P-gp inhibition.
What this interaction means in plain words
Dexamethasone-tobramycin and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by dexamethasone and P-gp inhibition by glecaprevir/pibrentasvir.
What to do
With systemic dexamethasone, monitor for virologic response and corticosteroid adverse effects. Local use needs no adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Glecaprevir / pibrentasvir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Frequently asked questions
Can I take Dexamethasone-tobramycin with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic dexamethasone may induce CYP3A4 and lower glecaprevir/pibrentasvir exposure, risking reduced antiviral efficacy. The combination may also raise dexamethasone through P-gp inhibition.
How serious is the interaction between Dexamethasone-tobramycin and Glecaprevir / pibrentasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, monitor for virologic response and corticosteroid adverse effects. Local use needs no adjustment.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
