Drug interactions
Dexamethasone-tobramycin + Indinavir
Severity: Moderate
Dexamethasone-tobramycin and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may raise dexamethasone concentrations, increasing the risk of corticosteroid effects such as adrenal suppression and Cushing features with prolonged use. Dexamethasone may in turn lower indinavir levels through CYP3A4 induction, risking reduced antiviral efficacy.
What this interaction means in plain words
Dexamethasone-tobramycin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4 and P-glycoprotein, increasing dexamethasone exposure, while dexamethasone induces CYP3A4 and may lower indinavir concentrations.
What to do
Use the lowest effective dexamethasone dose for the shortest time and monitor for corticosteroid toxicity. Monitor HIV viral load and indinavir response during prolonged dexamethasone therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Frequently asked questions
Can I take Dexamethasone-tobramycin with Indinavir?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and may raise dexamethasone concentrations, increasing the risk of corticosteroid effects such as adrenal suppression and Cushing features with prolonged use. Dexamethasone may in turn lower indinavir levels through CYP3A4 induction, risking reduced antiviral efficacy.
How serious is the interaction between Dexamethasone-tobramycin and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dexamethasone dose for the shortest time and monitor for corticosteroid toxicity. Monitor HIV viral load and indinavir response during prolonged dexamethasone therapy.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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