Drug interactions
Dexamethasone-tobramycin + Ioversol
Severity: Moderate
Dexamethasone-tobramycin and Ioversol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast media can cause contrast-associated kidney injury, and tobramycin is itself nephrotoxic and ototoxic. Given together, the risk of acute kidney injury rises, and impaired clearance can then raise aminoglycoside exposure. The topical ophthalmic route limits systemic tobramycin exposure, but any systemic use carries this concern.
What this interaction means in plain words
Dexamethasone-tobramycin and Ioversol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from contrast-induced tubular injury and aminoglycoside accumulation in renal tubular cells.
What to do
If tobramycin is given systemically, ensure hydration, check serum creatinine before and after contrast, and delay nonurgent contrast when renal function is impaired. Consider tobramycin levels and dose adjustment if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Ioversol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Frequently asked questions
Can I take Dexamethasone-tobramycin with Ioversol?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Ioversol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated contrast media can cause contrast-associated kidney injury, and tobramycin is itself nephrotoxic and ototoxic. Given together, the risk of acute kidney injury rises, and impaired clearance can then raise aminoglycoside exposure. The topical ophthalmic route limits systemic tobramycin exposure, but any systemic use carries this concern.
How serious is the interaction between Dexamethasone-tobramycin and Ioversol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If tobramycin is given systemically, ensure hydration, check serum creatinine before and after contrast, and delay nonurgent contrast when renal function is impaired. Consider tobramycin levels and dose adjustment if renal function declines.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
