Drug interactions
Dexamethasone-tobramycin + Lonapegsomatropin
Severity: Moderate
Dexamethasone-tobramycin and Lonapegsomatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which reduces conversion of cortisone to cortisol. In patients on replacement glucocorticoids, starting lonapegsomatropin may lower glucocorticoid effect and unmask adrenal insufficiency.
What this interaction means in plain words
Dexamethasone-tobramycin and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Lonapegsomatropin belongs to Endocrine.
Why it happens
Growth hormone inhibits 11-beta-HSD1, reducing activation of cortisone and thereby glucocorticoid effect.
What to do
Monitor for adrenal insufficiency symptoms after starting lonapegsomatropin and increase glucocorticoid maintenance or stress doses if required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Dexamethasone-tobramycin with Lonapegsomatropin?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which reduces conversion of cortisone to cortisol. In patients on replacement glucocorticoids, starting lonapegsomatropin may lower glucocorticoid effect and unmask adrenal insufficiency.
How serious is the interaction between Dexamethasone-tobramycin and Lonapegsomatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adrenal insufficiency symptoms after starting lonapegsomatropin and increase glucocorticoid maintenance or stress doses if required.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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