Drug interactions
Dexamethasone-tobramycin + Olaparib
Severity: Moderate
Dexamethasone-tobramycin and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone can induce CYP3A4 and may reduce olaparib exposure, potentially lowering its anticancer effect. The induction is weaker than that of strong inducers such as rifampin. Topical use has negligible effect.
What this interaction means in plain words
Dexamethasone-tobramycin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Olaparib belongs to Oncology.
Why it happens
CYP3A4 induction by dexamethasone increases olaparib metabolism.
What to do
Monitor for reduced olaparib response during prolonged systemic dexamethasone therapy. Prefer a non-inducing alternative where practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Olaparib?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone can induce CYP3A4 and may reduce olaparib exposure, potentially lowering its anticancer effect. The induction is weaker than that of strong inducers such as rifampin. Topical use has negligible effect.
How serious is the interaction between Dexamethasone-tobramycin and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced olaparib response during prolonged systemic dexamethasone therapy. Prefer a non-inducing alternative where practical.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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