Drug interactions
Dexamethasone-tobramycin + Sofosbuvir / velpatasvir
Severity: Moderate
Dexamethasone-tobramycin and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce enzymes and transporters involved in velpatasvir and sofosbuvir disposition, potentially lowering hepatitis C antiviral exposure. The effect is likely modest, but reduced exposure could affect cure rates.
What this interaction means in plain words
Dexamethasone-tobramycin and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 and P-gp by dexamethasone may reduce velpatasvir and sofosbuvir exposure.
What to do
Avoid prolonged systemic dexamethasone where possible and confirm sustained virologic response. Short courses are generally acceptable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Frequently asked questions
Can I take Dexamethasone-tobramycin with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may induce enzymes and transporters involved in velpatasvir and sofosbuvir disposition, potentially lowering hepatitis C antiviral exposure. The effect is likely modest, but reduced exposure could affect cure rates.
How serious is the interaction between Dexamethasone-tobramycin and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged systemic dexamethasone where possible and confirm sustained virologic response. Short courses are generally acceptable.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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