Drug interactions
Dexamethasone-tobramycin + Somatropin
Severity: Moderate
Dexamethasone-tobramycin and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Supraphysiologic glucocorticoid doses can blunt the growth-promoting effect of growth hormone, which matters particularly in children. Growth hormone also alters cortisol activation, which may unmask adrenal insufficiency in patients on glucocorticoid replacement.
What this interaction means in plain words
Dexamethasone-tobramycin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Somatropin belongs to Endocrine.
Why it happens
Glucocorticoids antagonize growth hormone action, and somatropin inhibits 11-beta-HSD1, altering cortisol activation.
What to do
Use the lowest effective glucocorticoid dose and monitor growth velocity in children. Reassess glucocorticoid replacement dosing after starting somatropin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Dexamethasone-tobramycin with Somatropin?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Supraphysiologic glucocorticoid doses can blunt the growth-promoting effect of growth hormone, which matters particularly in children. Growth hormone also alters cortisol activation, which may unmask adrenal insufficiency in patients on glucocorticoid replacement.
How serious is the interaction between Dexamethasone-tobramycin and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective glucocorticoid dose and monitor growth velocity in children. Reassess glucocorticoid replacement dosing after starting somatropin.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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