Drug interactions
Dexamethasone-tobramycin + Tenofovir df
Severity: Moderate
Dexamethasone-tobramycin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir DF and aminoglycosides can each damage the renal tubules, and their combination may increase nephrotoxicity and tenofovir exposure through reduced renal elimination. The risk is mainly with systemic tobramycin, not topical or ophthalmic use.
What this interaction means in plain words
Dexamethasone-tobramycin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal tubular toxicity and competition for renal elimination.
What to do
Monitor serum creatinine and phosphate when systemic tobramycin is used with tenofovir DF, and consider alternatives to nephrotoxic combinations if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Tenofovir df, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Frequently asked questions
Can I take Dexamethasone-tobramycin with Tenofovir df?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir DF and aminoglycosides can each damage the renal tubules, and their combination may increase nephrotoxicity and tenofovir exposure through reduced renal elimination. The risk is mainly with systemic tobramycin, not topical or ophthalmic use.
How serious is the interaction between Dexamethasone-tobramycin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and phosphate when systemic tobramycin is used with tenofovir DF, and consider alternatives to nephrotoxic combinations if renal function declines.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
